Relation of Left Ventricular Function, Mass, and Volume to NT-proBNP in Type 1 Diabetic Patients

  1. Anne Sofie Astrup, MD1,
  2. Won Yong Kim, MD23,
  3. Lise Tarnow, MD1,
  4. René M. Botnar, PHD4,
  5. Cheryl Simonsen, RT3,
  6. Lau Brix, MSC3,
  7. Lotte Pietraszek1,
  8. Peter Riis Hansen, MD5,
  9. Warren J. Manning, MD6 and
  10. Hans-Henrik Parving, MD7
  1. 1Steno Diabetes Center, Gentofte, Denmark
  2. 2Department of Cardiology, Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark
  3. 3MR-Center, Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark
  4. 4Department of Nuclear Medicine, Technical University Munich, Munich, Germany
  5. 5Gentofte Hospital, Gentofte, Denmark
  6. 6Department of Medicine, Cardiovascular Division, and the Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
  7. 7Department of Medical Endocrinology, Rigshospitalet, Copenhagen, Denmark
  1. Corresponding author: Anne Sofie Astrup, Steno Diabetes Center, Niels Steensensvej 2, 2820, Denmark. E-mail: ansa{at}steno.dk

Abstract

OBJECTIVES—To measure left ventricular mass (LVM), left ventricular volumes, and left ventricular function (LVF) in a cohort of type 1 diabetic patients and to correlate measures of imaging to NH2-terminal pro-brain natriuretic peptide (NT-proBNP).

RESEARCH DESIGN AND METHODS—In a cross-sectional study, all patients with type 1 diabetes underwent cardiovascular magnetic resonance imaging. We included 63 patients with diabetic nephropathy and 73 patients with normoalbuminuria.

RESULTS—All patients had normal global LVF. LVM was increased in patients with diabetic nephropathy compared with patients with persistent normoalbuminuria. Patients with nephropathy had smaller left ventricular volumes and increased levels of NT-proBNP. Linear regression analysis in patients with diabetic nephropathy showed that NT-proBNP and creatinine were associated with LVM.

CONCLUSIONS—Increased LVM is identified in asymptomatic type 1 diabetic patients with nephropathy compared with normoalbuminuric patients. Elevated levels of NT-proBNP were associated with increased LVM, which are both markers of increased cardiovascular risk.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 5 February 2008. DOI: 10.2337/dc07-1536.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    • Accepted January 23, 2008.
    • Received August 6, 2007.
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  1. Published online before print February 5, 2008, doi: 10.2337/dc07-1536 Diabetes Care May 2008 vol. 31 no. 5 968-970
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