C-Reactive Protein in Relation to the Development of Microalbuminuria in Type 1 Diabetes

The Oxford Regional Prospective Study

  1. M. Loredana Marcovecchio, MD12,
  2. Cosimo Giannini, MD2,
  3. Barry Widmer, BSC1,
  4. R. Neil Dalton, PHD3,
  5. Stefano Martinotti, MD4,
  6. Francesco Chiarelli, MD2 and
  7. David B. Dunger, MD1
  1. 1University Department of Paediatrics, Addenbrooke's Hospital, Cambridge, U.K.
  2. 2University Department of Paediatrics, Chieti, Italy
  3. 3WellChild Laboratory, Evelina Children's Hospital, London, U.K.
  4. 4Department of Pathology, Chieti, Italy
  1. Corresponding author: David B. Dunger, University Department of Paediatrics, Addenbrooke's Hospital, Hills Rd., Cambridge CB22QQ, U.K. E-mail: dbd25{at}cam.ac.uk

Abstract

OBJECTIVES—To perform a longitudinal evaluation of high-sensitivity C-reactive protein (hs-CRP) in young people with type 1 diabetes in relation to the development of microalbuminuria (MA).

RESEARCH DESIGN AND METHODS—hs-CRP was measured in 329 blood samples collected from 49 subjects with type 1 diabetes with MA and 49 normoalbuminuric subjects matched for age, sex, and duration of diabetes.

RESULTS—In subjects developing MA, a progressive rise in hs-CRP was detected with levels significantly higher in the years after the onset of MA when compared with levels before MA onset (P = 0.003; age-adjusted P = 0.06). After the onset of MA, hs-CRP levels were significantly higher in subjects with MA when compared with normoalbuminuric subjects (median 1.9 mg/l [range 0.2–9.8] vs. 1.1 mg/l [0.2–6.4]; P = 0.02; adjusted P = 0.036).

CONCLUSIONS—In this population of young subjects with type 1 diabetes, there was a significant increase in hs-CRP levels after the onset of MA, likely reflecting a general state of inflammation.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 30 January 2008. DOI: 10.2337/dc07-2101.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    • Accepted January 20, 2008.
    • Received November 1, 2007.
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  1. Published online before print January 30, 2008, doi: 10.2337/dc07-2101 Diabetes Care May 2008 vol. 31 no. 5 974-976
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