Acanthosis Nigricans Among Women With Gestational Diabetes Mellitus and Risk of Adverse Pregnancy Outcomes
- Julie Daitchman, MD1,
- Marian J. Vermeulen, BSCN, MHSC2 and
- Joel G. Ray, MD, MSC3
- 1Division of Endocrinology and Metabolism, University of Toronto, Toronto, Canada
- 2Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Canada
- 3Obstetrics and Gynecology and Health Policy Management and Evaluation, St. Michael's Hospital, University of Toronto, Toronto, Canada
- Corresponding author: Dr. J. Ray, Medicine, St. Michael's Hospital, University of Toronto, Inner City Health Research Unit, 30 Bond St., Toronto, Ontario M5B 1W8, Canada. E-mail: rayj{at}smh.toronto.on.ca
Acanthosis nigricans (AN) is a cutaneous manifestation of insulin resistance (1). Among women with gestational diabetes mellitus (GDM), it is not known whether AN is associated with greater need for insulin therapy in pregnancy or adverse perinatal outcomes.
We performed a prospective cohort study of consecutive women with GDM or impaired glucose tolerance and a singleton pregnancy referred to the Diabetes in Pregnancy Clinic at St. Michael's Hospital in inner city Toronto. Patients received dietary counseling and began blood glucose testing four times a day. At the initial clinic visit, each woman was examined for AN of …
