Early Subclinical Atherosclerosis in Women With Previous Gestational Diabetes Mellitus
- Laura Volpe, MD1,
- Ilaria Cuccuru, MD1,
- Cristina Lencioni, MD1,
- Vinicio Napoli, MD2,
- Alessandra Ghio, MD1,
- Carmen Fotino, PHS1,
- Alessandra Bertolotto, MD1,
- Giuseppe Penno, MD1,
- Luca Benzi, MD1,
- Stefano Del Prato, MD1 and
- Graziano Di Cianni, MD1
- 1Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
- 2Department of Radiology, University of Pisa, Pisa, Italy
- Corresponding author: Dr. Graziano Di Cianni, Endocrinology and Metabolism, Ospedale di Cisanello, Via Paradisa, 2, I-56126 Pisa, Italy. E-mail: dicianni{at}immr.med.unipi.it
To determine if women with previous gestational diabetes mellitus (pGDM), a population at high risk for type 2 diabetes and metabolic syndrome (1), have signs of subclinical atherosclerosis, we measured carotid intimal-medial thickness (IMT) and multiple cardiovascular risk factors in 28 women with and 24 without pGDM (control group) 2 years after delivery. A 75-g 2-h oral glucose tolerance test was performed for assessment of glucose tolerance, area under the glucose curve (AUCgluc), insulin sensitivity index, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, oxidized LDL (oxLDL), C-reactive protein (CRP), adiponectin, and fibrinogen. Family history, anthropometric parameters, and blood pressure were recorded. IMT was measured at four segments of …
