Should Nonalcoholic Fatty Liver Disease Be Included in the Definition of Metabolic Syndrome? A Cross-Sectional Comparison With Adult Treatment Panel III Criteria in Nonobese Nondiabetic Subjects

Response to Sookoian et al.

  1. Giovanni Musso, MD1,
  2. Roberto Gambino, MD2,
  3. Simona Bo, MD2 and
  4. Maurizio Cassader, MD2
  1. 1Gradenigo Hospital, Turin, Italy
  2. 2Department of Internal Medicine, University of Turin, Turin, Italy
  1. Corresponding author: Giovanni Musso, Gradenigo Hospital, Corso R. Margherita 8, 10132 Torino, Italy. E-mail: giovanni_musso{at}

The findings of Sookoian et al. (1) expand our recent research (2) and further suggest that the liver, the vessel wall, and adipose tissue share common inflammatory pathways. Intracellular adhesion molecule-1 (ICAM-1) is a transmembrane adhesion molecule involved in leukocyte migration to inflammatory …

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