No Apparent Local Effect of Insulin on Microdialysis Continuous Glucose- Monitoring Measurements
- Jeroen Hermanides, MD,
- Iris M. Wentholt, MD,
- Augustinus A. Hart, PHD,
- Joost B. Hoekstra, MD, PHD and
- J. Hans DeVries, MD, PHD
- Corresponding author: Jeroen Hermanides, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, Netherlands. E-mail: j.hermanides{at}amc.uva.nl
Abstract
OBJECTIVE—Data investigating the possible disturbing influence of insulin in the vicinity of continuous glucose monitoring (CGM) is lacking. We investigated the hypothesis that high local insulin concentrations would interfere with sensor readings.
RESEARCH DESIGN AND METHODS—Two microdialysis sensors were inserted in the periumbilical region of 10 continuous subcutaneous insulin infusion (CSII)-treated type 1 patients. A test sensor was inserted as close as possible to the insulin catheter and compared with a control sensor. Glucose peak and nadir were induced. Horizontal and vertical shifts were assessed using curve fitting, and mean absolute difference (MAD) between paired blood and sensor values were calculated.
RESULTS—Curve fitting showed no significant differences between the two sensors. MAD ± SD was 8.50 ± 3.47% for the test sensor and 9.21 ± 3.17% for the control sensor, P = 0.72.
CONCLUSIONS—Microdialysis CGM can be accurately performed in the proximity of CSII systems.
- CGM, continuous glucose monitoring
- CSII, continuous subcutaneous insulin infusion
- MAD, mean absolute difference
Footnotes
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Published ahead of print at http://care.diabetesjournals.org on 10 March 2008. DOI: 10.2337/dc08-0145.
Additional information for this article can be found in an online appendix at http://dx.doi.org/10.2337/dc08-0415.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.
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- Accepted February 26, 2008.
- Received January 22, 2008.
- DIABETES CARE
