Role of Adiponectin in Matching of Fetal and Placental Weight in Mothers With Type 1 Diabetes
- Scott M. Nelson, PHD, MRCOG,
- Dilys J. Freeman, PHD,
- Naveed Sattar, PHD, FRCP and
- Robert S. Lindsay, PHD, FRCP
- Corresponding author: Dr. Scott Nelson, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, U.K. G31 2ER. E-mail: s.nelson{at}clinmed.gla.ac.uk
Abstract
OBJECTIVE—To assess the association of fetal hormones with placental growth and fetal weight–to–placental weight ratio index (FPI) in pregnancies complicated by maternal diabetes.
RESEARCH DESIGN AND METHODS—We conducted a prospective study using umbilical venous blood samples taken at birth from 122 offspring of mothers with type 1 diabetes (OT1D) and 46 control subjects.
RESULTS—Placental weight (P = 0.009) and gestation-adjusted birth weight (P < 0.001) were increased in OT1D, but FPI was unaltered (P = 0.33). Placental weight correlated with birth weight (P < 0.001) and cord leptin (P < 0.001) in control subjects and OT1D, with further relationships with cord insulin, IGF-1, IGF-binding protein-3 (IGFBP-3), and triceps and subscapular thickness in OT1D. FPI was associated with adiponectin in both groups, even after adjustment for confounders.
CONCLUSIONS—Placental and fetal growth show a parallel increase in mothers with type 1 diabetes. The possible role of adiponectin in matching of fetal and placental growth merits further study.
- CRP, C-reactive protein
- CTV, contribution to variance
- FPI, fetal weight–to–placental weight ratio index
- IGFBP-3, IGF-binding protein-3
- OT1D, offspring of mothers with type 1 diabetes
Footnotes
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Published ahead of print at http://care.diabetesjournals.org on 13 March 2008. DOI: 10.2337/dc07-2195.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.
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- Accepted March 10, 2008.
- Received November 19, 2007.
- DIABETES CARE
