Plasma Carotenoids and Onset of Dysglycemia in an Elderly Population

Results of the Epidemiology of Vascular Ageing Study

  1. Tasnime N. Akbaraly, PHD123,
  2. Annick Fontbonne, MD, PHD4,
  3. Alain Favier, PHD5 and
  4. Claudine Berr, MD, PHD1
  1. 1Institut National de la Santé et de la Recherche Medicalé (INSERM) U888, Université Montpellier I, Montpellier, France
  2. 2Department of Epidemiology and Public Health, University College London, London, U.K.
  3. 3Department of Human Nutrition Research, Medical Research Council, Cambridge, U.K.
  4. 4Institute of Research for Development UR024, Montpellier, France
  5. 5Département de Biologie Intégrée, CHU de Grenoble, Grenoble, France
  1. Corresponding author: Tasnime Akbaraly, t.akbaraly{at}ucl.ac.uk

Abstract

OBJECTIVE—The hypothesis of carotenoid having a preventive role in diabetes is suggested by their antioxidant properties. In this report, we investigated the relationship between baseline total plasma carotenoid levels and 9-year onset of dysglycemia (impaired fasting glucose or type 2 diabetes) in a healthy elderly population.

RESEARCH DESIGN AND METHODS—The Epidemiology of Vascular Ageing Study is a 9-year longitudinal study including 1,389 volunteers aged 59–71 years. Fasting plasma glucose was measured at baseline and at 2, 4, and 9 years after inclusion. The relationship between plasma carotenoid at baseline and incidence of dysglycemia was determined by Cox proportional hazards regression analysis adjusting for potential confounders.

RESULTS—At 9 years, 127 incident cases of dysglycemia had occurred. Risk of dysglycemia was significantly lower in participants with plasma carotenoid in the highest quartile (Q4) compared with participants in the lowest quartile (Q1) (Q4 vs. Q1: relative risk 0.26 [95% CI 0.14–0.49], P < 10−4; Q3 vs. Q1: 0.55 [0.34–0.89], P = 0.01; and Q2 vs. Q1: 0.82 [0.51–1.31], P = 0.40). After controlling for sociodemographic variables, lifestyle habits, cardiovascular disease, blood pressure, BMI, and lipid profile, risk of dysglycemia remained significantly lower in participants in the highest quartile of total plasma carotenoid compared with participants in the lowest quartile (Q4 vs. Q1: 0.42 [0.22–0.82], P = 0.01; Q3 vs. Q1: 0.69 [0.41–1.15], P = 0.16; and Q2 vs. Q1: 0.80 [0.48–1.32], P = 0.38).

CONCLUSIONS—This study prospectively confirms that plasma carotenoid levels have an independent relationship to onset of dysglycemia.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 4 April 2008.

    Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted April 2, 2008.
    • Received November 2, 2007.
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  1. Published online before print April 4, 2008, doi: 10.2337/dc07-2113 Diabetes Care July 2008 vol. 31 no. 7 1355-1359
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