Periodontal Disease and Incident Type 2 Diabetes

Results from the First National Health and Nutrition Examination Survey and its Epidemiologic Follow-Up Study

  1. Ryan T. Demmer, PHD, MPH1,
  2. David R. Jacobs, Jr., PHD2 and
  3. Moïse Desvarieux, MD, PHD13
  1. 1Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York
  2. 2Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, and the Department of Nutrition, University of Oslo, Oslo, Norway
  3. 3Institut National de la Santé et de la Recherche Médicale and Unité Mixte de Recherche S707, Universite Pierre et Marie Curie-Paris6, Paris, France
  1. Corresponding author: Ryan Demmer, rtd2106{at}columbia.edu

Abstract

OBJECTIVE—Type 2 diabetes and periodontal disease are known to be associated, but the temporality of this relationship has not been firmly established. We investigated whether baseline periodontal disease independently predicts incident diabetes over two decades of follow-up.

RESEARCH DESIGN AND METHODS—A total of 9,296 nondiabetic male and female National Health and Nutrition Examination Survey (NHANES I) participants aged 25–74 years who completed a baseline dental examination (1971–1976) and had at least one follow-up evaluation (1982–1992) were studied. We defined six categories of baseline periodontal disease using the periodontal index. Of 7,168 dentate participants, 47% had periodontal index = 0 (periodontally healthy); the remaining were classified into periodontal index quintiles. Incident diabetes was defined by 1) death certificate (ICD-9 code 250), 2) self-report of diabetes requiring pharmacological treatment, or 3) health care facility stay with diabetes discharge code. Multivariable logistic regression models assessed incident diabetes odds across increasing levels of periodontal index in comparison with periodontally healthy participants.

RESULTS—The adjusted odds ratios (ORs) for incident diabetes in periodontal index categories 1 and 2 were not elevated, whereas the ORs in periodontal index categories 3 through 5 were 2.26 (95% CI 1.56–3.27), 1.71 (1.0–2.69), and 1.50 (0.99–2.27), respectively. The OR in edentulous participants was 1.30 (1.00–1.70). Dentate participants with advanced tooth loss had an OR of 1.70 (P < 0.05) relative to those with minimal tooth loss.

CONCLUSIONS—Baseline periodontal disease is an independent predictor of incident diabetes in the nationally representative sample of NHANES I.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 4 April 2008.

  • These data originate from the National Center for Health Statistics (NCHS) at the Centers for Disease Control and Prevention. The NCHS does not claim credit or responsibility for the analyses, findings, or conclusion reported herein.

  • Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

  • The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    • Accepted March 31, 2008.
    • Received January 12, 2008.
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  1. Diabetes Care vol. 31 no. 7 1373-1379
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