Inflammation Among Women With a History of Gestational Diabetes Mellitus and Diagnosed Diabetes in the Third National Health and Nutrition Examination Survey
- Catherine Kim, MD, MPH1,
- Yiling J. Cheng, MD, PHD2 and
- Gloria L. Beckles, MD, MSC2
- 1Department of Medicine, University of Michigan, Ann Arbor, Michigan
- 2Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia
- Corresponding author: Catherine Kim, cathkim{at}umich.edu
Abstract
OBJECTIVE—We compared inflammatory markers among women with a history of gestational diabetes mellitus (hGDM), women with diagnosed diabetes, and unaffected women in a population-based sample.
RESEARCH DESIGN AND METHODS—We conducted cross-sectional analyses of 6,346 nonpregnant women in the Third National Health and Nutrition Examination Survey (1988–1994). Women were classified as having hGDM (n = 87), diagnosed diabetes (n = 244), or neither condition (n = 6,015). Inflammatory markers included ferritin, leukocyte count, and C-reactive protein levels.
RESULTS—After adjustment, women with diagnosed diabetes had the most marked differences in inflammatory markers compared with unaffected women. Differences between unaffected women and women with hGDM were minimal.
CONCLUSIONS—Women with diagnosed diabetes have less favorable inflammation profiles than unaffected women and greater ferritin levels than women with hGDM. After adjustment, women with hGDM who have not developed diagnosed diabetes have inflammation profiles similar to those of unaffected women.
Footnotes
-
Published ahead of print at http://care.diabetesjournals.org on 28 March 2008.
-
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
-
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
-
- Accepted March 21, 2008.
- Received December 12, 2007.
- DIABETES CARE
