Adipose Tissue Lipolysis Is Upregulated in Lean and Obese Men During Acute Resistance Exercise
- Athanasios Chatzinikolaou, MSC1,
- Ioannis Fatouros, PHD1,
- Anatoli Petridou, PHD2,
- Athanasios Jamurtas, PHD3,
- Alexandra Avloniti, PHD1,
- Ioannis Douroudos, MSC1,
- George Mastorakos, MD4,
- Christina Lazaropoulou, BSC5,
- Ioannis Papassotiriou, PHD5,
- Symeon Tournis, MD6,
- Asimina Mitrakou, MD4 and
- Vassilis Mougios, PHD2
- 1Department of Physical Education and Sports Science, University of Thrace, Komotini, Greece
- 2Department of Physical Education and Sport Science, Aristotle University of Thessaloniki, Thessaloniki, Greece
- 3Department of Physical Education and Sports Science, University of Thessaly, Trikala, Greece
- 4Endocrine Unit, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece
- 5Department of Clinical Biochemistry, Aghia Sophia Hospital, Athens, Greece
- 6Garofalidis Laboratory for Musculoskeletal System Research, Athens University, Athens, Greece
- Corresponding author: Vassilis Mougios, mougios{at}phed.auth.gr
Abstract
OBJECTIVE—To investigate the effect of acute resistance exercise on adipose tissue triacylglycerol lipase activity (TGLA) in lean and obese men.
RESEARCH DESIGN AND METHODS—Nine lean and eight obese men performed 30 min of circuit resistance exercise. Adipose tissue and blood were sampled during exercise for TGLA, metabolite, and hormone determinations. Respiratory exchange ratio (RER) was measured throughout exercise.
RESULTS—Energy expenditure of exercise relative to body mass was higher in the lean and RER was higher in the obese men, suggesting lower fat oxidation. TGLA increased 18-fold at 5 min of exercise in the lean men and 16-fold at 10 min of exercise in the obese men. The delayed lipolytic activation in the obese men was reflected in serum nonesterified fatty acid and glycerol concentrations. Plasma insulin increased in the obese but did not change in the lean men.
CONCLUSIONS—Resistance exercise upregulated adipose tissue lipolysis and enhanced energy expenditure in lean and obese men, with a delayed lipolytic activation in the obese men.
Footnotes
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Published ahead of print at http://care.diabetesjournals.org on 28 March 2008.
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- Accepted March 25, 2008.
- Received January 11, 2008.
- DIABETES CARE
