Improved Peripheral Perfusion During Endothelin-A Receptor Blockade in Patients With Type 2 Diabetes and Critical Limb Ischemia
- Majid Kalani, MD, PHD1,
- John Pernow, MD, PHD2,
- Joakim Bragd, MD1 and
- Gun Jörneskog, MD, PHD1
- 1Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden
- 2Department of Cardiology, Karolinska University Hospital, Karolinska Institute, Solna, Stockholm, Sweden
- Corresponding author: Dr. Majid Kalani, majid.kalani{at}ds.se
Endothelin (ET)-1 levels are increased in patients with type 2 diabetes and may contribute to vascular complications and insulin resistance. Recently, we showed that ETA receptor blockade improves nutritive skin capillary circulation in patients with type 2 diabetes and microangiopathy (1).
In this study, we investigated the effect of ETA receptor blockade on peripheral micro- and macrocirculation in six patients (two female/four male; mean age 79 ± 6 years) with type 2 diabetes and critical limb ischemia (toe blood pressure …
