Association of 1,5-Anhydroglucitol and 2-h Postprandial Blood Glucose in Type 2 Diabetic Patients

  1. Christoph Stettler, MD1,2,
  2. Matthias Stahl, MD3,
  3. Sabin Allemann, PHD1,2,
  4. Peter Diem, MD1,
  5. Kurt Schmidlin, DMD2,
  6. Marcel Zwahlen, PHD2,
  7. Walter Riesen, PHD4,
  8. Ulrich Keller, MD5 and
  9. Emanuel Christ, MD1
  1. 1Division of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital, Bern, Switzerland
  2. 2Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
  3. 3Department of Internal Medicine, Cantonal Hospital, Olten, Switzerland
  4. 4Institute of Clinical Chemistry, Kantonsspital, St. Gallen, Switzerland
  5. 5Division of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital, Basel, Switzerland
  1. Corresponding author: Christoph Stettler, christoph.stettler{at}insel.ch

Abstract

OBJECTIVE—To assess the association of 1,5-anhydroglucitol (1,5-AG) with 2-h postprandial glucose values in type 2 diabetic patients followed over 12 months in an outpatient setting.

RESEARCH DESIGN AND METHODS—In 55 patients, we examined self-measured postprandial blood glucose values for correlations with 1,5-AG values over prespecified preceding time periods (3 days, 1 week, and weekly up to 12 weeks).

RESULTS—The correlation coefficients for postprandial glucose values were −0.34 (P < 0.05) for 3 days, −0.38 (P < 0.001) for 1 week, and −0.40 (P < 0.001) for 2 weeks preceding the measurement of 1,5-AG. Correlations declined for time periods >2 weeks before measurement of 1,5-AG. The correlation was lower with fasting/preprandial plasma glucose levels. There was no time dependency for the correlation between A1C and fasting or postprandial glucose.

CONCLUSIONS—1,5-AG best reflected the 2-h postprandial glucose values of the 2 previous weeks.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 21 April 2008.

    Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Received February 22, 2008.
    • Accepted April 16, 2008.
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  1. Published online before print April 21, 2008, doi: 10.2337/dc08-0385 Diabetes Care August 2008 vol. 31 no. 8 1534-1535
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