Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function
- Sebastiaan Hammer, MSC1,2,
- Jacqueline T. Jonker, MD1,2,
- Hildo J. Lamb, MD, PHD2,
- Rutger W. van der Meer, MD2,
- Wendy Zondag, MD1,
- Jan M. Sepers, MD, PHD3,
- Albert de Roos, MD, PHD2,
- Johannes W.A. Smit, MD, PHD1 and
- Johannes A. Romijn, MD, PHD1
- 1Department of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
- 2Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands
- 3Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, the Netherlands
- Corresponding author: S. Hammer, s.hammer{at}lumc.nl
Abstract
OBJECTIVE—To evaluate the effects of hyperglycemia due to partial insulin deprivation on myocardial triglyceride (TG) content and myocardial function in patients with type 1 diabetes.
RESEARCH DESIGN AND METHODS—Myocardial and hepatic TG content and left ventricular (LV) function were measured by magnetic resonance (MR) spectroscopy and MR imaging during optimal glucoregulation and after 24 h of partial insulin deprivation (n = 10).
RESULTS—Mean insulin infusion rate was 45 ± 5 units at baseline, whereas it was 27 ± 5 units during hyperglycemia (per 24 h, P < 0.001). Plasma glucose levels increased from 8.4 ± 0.6 to 15.9 ± 0.8 mmol/l (P < 0.001), and plasma levels of nonesterified fatty acids from 0.31 ± 0.05 to 0.46 ± 0.07 mmol/l (P = 0.015). Hyperglycemia had no effects on myocardial or hepatic TG content and LV function.
CONCLUSIONS—Short-term hyperglycemic dysregulation does not modulate myocardial or hepatic TG content or myocardial function, despite considerable metabolic adaptations.
Footnotes
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Published ahead of print at http://care.diabetesjournals.org on 5 May 2008.
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- Received March 12, 2008.
- Accepted April 30, 2008.
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