Dysglycemia and a History of Reproductive Risk Factors
- Sarah D. McDonald, MD, MSC1,
- Salim Yusuf, MD, DPHIL2,3,4,
- Patrick Sheridan, MSC4,
- Sonia S. Anand, MD, PHD2,4,
- Hertzel C. Gerstein, MD, MSC2,4,5 and
- for the DREAM Trial Investigators
- 1Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
- 2Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
- 3Division of Cardiology, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
- 4Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
- 5Division of Endocrinology and Metabolism, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
- Corresponding author: Sarah D. McDonald, mcdonals{at}mcmaster.ca
Abstract
OBJECTIVE—The purpose of this study was to identify reproductive risk factors associated with dysglycemia (diabetes, impaired glucose tolerance, and impaired fasting glucose) in a contemporary multiethnic population.
RESEARCH DESIGN AND METHODS—We studied 14,661 women screened with an oral glucose tolerance test for the Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication (DREAM) trial. Reproductive risk factors were compared in normoglycemic and dysglycemic women.
RESULTS—Dysglycemia was significantly associated with the number of children born (odds ratio 1.03 per child [95% CI 1.01–1.05]), age (1.05 per year [1.04–1.05]), non-European ancestry (1.09 [1.01–1.17]), preeclampsia/eclampsia (1.14 [1.02–1.27]), irregular periods (1.21 [1.07–1.36]), and gestational diabetes mellitus (GDM) (1.53 [1.35–1.74]). The relationship between GDM and dysglycemia did not differ across BMI tertiles (P = 0.84) nor did the relationships of other risk factors.
CONCLUSIONS—Reproductive factors, particularly GDM, are associated with dysglycemia in middle-aged women from many ethnicities. Reproductive factors can be used to counsel young women about their future risk of dysglycemia, whereas in middle age they may help screen for dysglycemia.
Footnotes
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Published ahead of print at http://care.diabetesjournals.org on 5 May 2008.
The funding organizations had no part in the design of the study; the collection, analysis, or interpretation of the data; or the decision to approve publication of the finished manuscript.
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received March 27, 2008.
- Accepted April 27, 2008.
- DIABETES CARE
