Association Between Raised Blood Pressure and Dysglycemia in Hong Kong Chinese
- Bernard M.Y. Cheung, PHD12,
- Nelson M.S. Wat, FRCP1,
- Annette W.K. Tso, MRCP(UK)1,
- Sidney Tam, FACB3,
- G. Neil Thomas, PHD4,
- Gabriel M. Leung, MD5,
- Hung Fat Tse, MD1,
- Jean Woo, MD6,
- Edward D. Janus, MD7,
- Chu Pak Lau, MD1,
- Tai Hing Lam, MD5 and
- Karen S.L. Lam, MD1
- 1Department of Medicine, University of Hong Kong, Hong Kong, China
- 2Department of Clinical Pharmacology, University of Birmingham, Birmingham, U.K.
- 3Clinical Biochemistry Unit, Queen Mary Hospital, Hong Kong, China
- 4Department of Public Health and Epidemiology, University of Birmingham, Birmingham, U.K.
- 5Department of Community Medicine, University of Hong Kong, Hong Kong, China
- 6Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China
- 7Department of Medicine, University of Melbourne, Western Hospital, Footscray, Victoria, Australia
- Corresponding author: Bernard M.Y. Cheung, b.cheung{at}bham.ac.uk
Abstract
OBJECTIVE—To investigate the association between raised blood pressure and dysglycemia.
RESEARCH DESIGN AND METHODS—We studied the association between raised blood pressure and dysglycemia in 1,862 subjects in the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort. We determined the factors predicting the development of diabetes and hypertension in 1,496 subjects who did not have either condition at baseline.
RESULTS—Diabetes and hypertension were both related to age, obesity indexes, blood pressure, glucose, HDL cholesterol, and triglycerides. Of subjects with diabetes, 58% had raised blood pressure. Of subjects with hypertension, 56% had dysglycemia. BMI and blood glucose 2 h after a 75-g oral glucose load were independent predictors of new-onset diabetes. Age, systolic blood pressure, and 2-h glucose were independent predictors of new-onset hypertension. BMI, systolic blood pressure, and 2-h glucose were independent predictors of the development of diabetes and hypertension together.
CONCLUSIONS—Diabetes and hypertension share common etiological factors. Patients with diabetes or hypertension should be screened and managed for the precursor of the other condition.
Footnotes
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Published ahead of print at http://care.diabetesjournals.org on 12 June 2008.
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- Accepted June 4, 2008.
- Received February 26, 2008.
- DIABETES CARE
