Effect of a Successful Intensive Lifestyle Program on Insulin Sensitivity and Glucose Tolerance in Obese Youth
- Melissa Shaw1,
- Mary Savoye, RD, CDE2,
- Anna Cali, MD1,
- James Dziura, PHD2,
- William V. Tamborlane, MD1 and
- Sonia Caprio, MD1
- 1Department of Pediatrics, Yale University, New Haven, Connecticut
- 2Yale Center for Clinical Investigation, Yale University School of Medicine, New Haven, Connecticut
- Corresponding author: Melissa Shaw, melissa.m.shaw{at}yale.edu
Abstract
OBJECTIVE—To evaluate the impact on glucose metabolism of a lifestyle program (the Yale Bright Bodies Program) for obese children.
RESEARCH DESIGN AND METHODS—Thirteen Bright Bodies and ten clinic-care control subjects who were part of a large randomized clinical trial had 75-g oral glucose tolerance tests at the beginning and end of the 12-month study.
RESULTS—Bright Bodies subjects had significantly greater decreases in weight, BMI, and body fat than clinic-care subjects, and the Bright Body subjects’ changes in body composition were accompanied by marked improvements in insulin sensitivity (P = 0.009) and glucose tolerance (P = 0.04).
CONCLUSIONS—An intensive lifestyle program that successfully reduces body weight and body fat can markedly improve insulin sensitivity and glucose metabolism in obese youth.
Footnotes
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Published ahead of print at http://care.diabetesjournals.org on 7 October 2008.
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- Accepted September 26, 2008.
- Received May 12, 2008.
- DIABETES CARE
