Response to Rodríguez-Segade et al. and Leslie and Kilpatrick
- David M. Nathan, MD and
- for the ADAG Study Group
- From the Massachusetts General Hospital Diabetes Center, Boston, Massachusetts
- Corresponding author: David M. Nathan, dnathan{at}partners.org
Rodríguez-Segade et al. (1) question the clinical usefulness of the estimated average glucose (eAG) developed by the A1C-Derived Average Glucose (ADAG) Study (2). They note that although the study met the a priori–specified criterion for acceptability (≥90% of subject values within 15% of the regression line between A1C and calculated mean glucose), the variability of the estimate makes the equation clinically useless. Furthermore, they state, without any supporting evidence, that the assumption that “A1C depends exclusively on average plasma glucose—is not justified.”
Leslie and Kilpatrick (3) remarkably resort to the Heisenberg uncertainty principle of quantum physics (which states the uncertainty of simultaneously measuring the position and momentum of a particle, owing in part to the perturbation of the particle as part of the measurement) to point out …
