Changes in Serum Adiponectin Concentrations Correlate With Changes in BMI, Waist Circumference, and Estimated Visceral Fat Area in Middle-Aged General Population
- Yukiyoshi Okauchi, MD1,
- Ken Kishida, MD1,
- Tohru Funahashi, MD1,
- Midori Noguchi, RN2,
- Tomoko Ogawa, RN2,
- Miwa Ryo, MD1,
- Kohei Okita, MD1,
- Hiromi Iwahashi, MD1,
- Akihisa Imagawa, MD1,
- Tadashi Nakamura, MD3,
- Yuji Matsuzawa, MD4 and
- Iichiro Shimomura, MD1
- 1Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan;
- 2Amagasaki City Office, General Affairs Bureau, Personal Department, Payroll Section, Employee Health Promotion Section, Amagasaki, Hyogo, Japan;
- 3Kawasaki Hospital, Kobe, Hyogo, Japan;
- 4Sumitomo Hospital, Osaka, Japan.
- Corresponding author: Ken Kishida, kkishida{at}imed2.med.osaka-u.ac.jp.
Adiponectin was identified as an adipocytokine in the human adipose tissue cDNA library. It has antiatherosclerotic and antidiabetic properties in experimental studies, and its blood levels are low in obesity, diabetes, cardiovascular diseases, and metabolic syndrome. Several studies have reported that weight reduction in massively obese subjects is associated with a rise in serum adiponectin (APN) concentration (1–3). However, the relationship between changes in APN and BMI, waist circumference (WC), and visceral fat accumulation (VFA) in general population has not been reported. The present study investigated 1-year change in APN (ΔAPN) in relation to changes in BMI (ΔBMI), WC …
