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Insulin Response in Relation to Insulin Sensitivity: An Appropriate β-Cell Response in Black South African Women

Response to Joffe and Distiller

  1. Julia H. Goedecke, PHD1,2,
  2. Estelle V. Lambert, PHD1,
  3. Naomi S. Levitt, MB, CHB, MD3,
  4. Tommy Olsson, MD4,
  5. Jonathan R. Seckl, MB, PHD5,
  6. Brian R. Walker, MD5 and
  7. Steven E. Kahn, MB, CHB6
  1. 1University of Cape Town/South African Medical Research Council Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa;
  2. 2South African Medical Research Council, Cape Town, South Africa;
  3. 3Endocrine Unit, Department of Medicine, University of Cape Town, Cape Town, South Africa;
  4. 4Department of Medicine, Umeå University, Umeå, Sweden;
  5. 5Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland;
  6. 6Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, U.S. Department of Veterans Affairs' Puget Sound Health Care System and the University of Washington, Seattle, Washington.
  1. Corresponding author: Julia H. Goedecke, julia.goedecke{at}uct.ac.za.

We are in agreement with Joffe and Distiller (1) that the pathogenesis of type 2 diabetes in black South Africans cannot be inferred from limited …

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