Significant Synergistic Effect of Peroxisome Proliferator–Activated Receptor γ C-2821T and Diabetes on the Risk of Ischemic Stroke
- Fang-I Hsieh, PHD1,2,
- Wei-Cheng Lo, MSC1,
- Huey-Juan Lin, MD, MPH3,
- Yi-Chen Hsieh, PHD1,
- Li-Ming Lien, MD, PHD4,
- Chyi-Huey Bai, PHD1,5,
- Hung-Pin Tseng, MD6 and
- Hung-Yi Chiou, PHD1,2
- 1School of Public Health, Taipei Medical University, Taipei, Taiwan;
- 2Dr. Chi-Chin Huang Stroke Research Center, Taipei Medical University, Taipei, Taiwan;
- 3Department of Neurology, Chi-Mei Medical Center, Tainan, Taiwan;
- 4Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan;
- 5Central Laboratory, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan;
- 6Department of Neurology, Lotung Poh-Ai Hospital, Lotung, Taiwan.
- Corresponding author: Hung-Yi Chiou, hychiou{at}tmu.edu.tw.
Abstract
OBJECTIVE To explore the relationship between the genetic polymorphisms of PPARγ (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARγ would modify the risk of ischemic stroke among patients with hypertension or diabetes.
RESEARCH DESIGN AND METHODS The case-control study was conducted with 537 ischemic stroke patients and 537 control subjects. A structured questionnaire was used to collect information on conventional cardiovascular risk factors and laboratory results. The genetic polymorphisms of PPARγ were determined by PCR–restriction fragment–length polymorphism.
RESULTS A significant interaction was seen between the −2821C allele and diabetes but not between this allele and hypertension. A markedly elevated risk of ischemic stroke (odds ratio 9.7) was found in the subjects with diabetes and the −2821C allele compared with that in those without these two risk factors.
CONCLUSIONS The −2821C allele of PPARγ was a strong predictor of ischemic stroke for diabetic patients.
Footnotes
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received April 15, 2009.
- Accepted July 27, 2009.
- © 2009 by the American Diabetes Association.
