Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers
Response to Liu et al.
- Marie Muller, MD1,
- Candice Trocme, PHD2,
- Francoise Morel, MD, PHD2,
- Serge Halimi, MD1 and
- Pierre Y. Benhamou, MD, PHD1
- 1Department of Endocrinology, Pôle Digidune, Centre Hospitalier Universitaire de Grenoble, Grenoble, France;
- 2Enzymology Laboratory, Department of Cell Biology and Pathology, Centre Hospitalier Universitaire de Grenoble, Grenoble, France.
- Corresponding author: Marie Muller, mmuller{at}chu-grenoble.fr.
In a recent study by Liu et al. (1), the complex mechanisms of diabetic foot ulcers were further elucidated. In a series of 62 ulcers, the authors report that they found—for the first time—a positive correlation between a high matrix metalloproteinase-9 (MMP-9)–to–tissue inhibitor of metalloproteinase-1 (TIMP-1) ratio and poor wound healing.
However, these are not the first data enhancing the putative role of MMP-9 in the pathogenesis of chronic wounds. Ladwig et al. (2) also described a positive correlation between a high MMP-9–to–TIMP-1 ratio and poor wound healing …
