Cross-Sectional Validation of Diabetes Risk Scores for Predicting Diabetes, Metabolic Syndrome, and Chronic Kidney Disease in Taiwanese
- Jou-Wei Lin, MD, PHD1,2,
- Yi-Cheng Chang, MD1,
- Hung-Yuan Li, MD, MS2,3,
- Yu-Fen Chien, MS1,
- Mei-Yu Wu, RN1,
- Ru-Yi Tsai, RN1,
- Yenh-Chen Hsieh, BS1,
- Yu-Jen Chen, BS1,
- Juey-Jen Hwang, MD, PHD2,3 and
- Lee-Ming Chuang, MD, PHD2,3
- 1Metabolic Syndrome and Diabetes Screening Program, National Taiwan University Hospital Yun-Lin Branch, Dou-Liou City, Taiwan;
- 2Department of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan;
- 3Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
- Corresponding authors: Lee-Ming Chuang, leeming{at}ntu.edu.tw, and Juey-Jen Hwang, jueyhwang{at}ntu.edu.tw.
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J.-W.L. and Y.-C.C. contributed equally to this work.
Abstract
OBJECTIVE To validate the performance of current diabetes risk scores (DRSs) based on simple clinical information in detecting type 2 diabetes, metabolic syndrome (MetSyn), and chronic kidney disease (CKD).
RESEARCH DESIGN AND METHODS The performance of 10 DRSs was evaluated in a cross-sectional population screening of 2,759 Taiwanese subjects.
RESULTS All DRSs significantly correlated with measures of insulin resistance, estimated glomerular filtration rate, and urine albumin excretion. The prevalence of screening-detected diabetes (SDM), MetSyn, and CKD increased with higher DRSs. For prediction of SDM, the Cambridge DRS by Griffin et al. and the Finnish DRS outperformed other DRSs in terms of discriminative power and model fit. For prediction of MetSyn and CKD, the Atherosclerosis Risk in Community Study score by Schmidt et al. outperformed other DRSs.
CONCLUSIONS Risk scores based on simple clinical information are useful to identify individuals at high risk for diabetes, MetSyn, and CKD in different ethnic populations.
Footnotes
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received April 14, 2009.
- Accepted August 18, 2009.
- © 2009 by the American Diabetes Association.
