Circulating Levels of Resistin and Risk of Type 2 Diabetes in Men and Women: Results From Two Prospective Cohorts
- Brian H. Chen, MPH1,
- Yiqing Song, MD, SCD2,
- Eric L. Ding, SCD34,
- Christian K. Roberts, PHD15,
- JoAnn E. Manson, MD, DRPH23,
- Nader Rifai, PHD6,
- Julie E. Buring, SCD237,
- J. Michael Gaziano, MD28 and
- Simin Liu, MD, SCD19
- 1Program on Genomics and Nutrition, Department of Epidemiology, UCLA School of Public Health, Los Angeles, California
- 2Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
- 3Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
- 4Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
- 5Department of Physiological Science, University of California, Los Angeles, California
- 6Department of Laboratory Medicine, Children's Hospital and Harvard Medical School, Boston, Massachusetts
- 7Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts
- 8Division of Aging, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
- 9Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California
- Corresponding author: Yiqing Song, ysong3{at}rics.bwh.harvard.edu
Abstract
OBJECTIVE—The purpose of this study was to investigate the role of circulating resistin levels in the development of type 2 diabetes using two prospective cohorts of well-characterized men and women.
RESEARCH DESIGN AND METHODS—We conducted two prospective case-control studies nested in the Women's Health Study (WHS) and Physicians’ Health Study II (PHS II). In the WHS, during a median of 10-years of follow-up, 359 postmenopausal women, who were apparently healthy at baseline and later developed type 2 diabetes, were prospectively matched with 359 healthy control subjects. In the PHS II, with 8 years of total follow-up, 170 men, who were apparently healthy at baseline and later developed type 2 diabetes, were matched with 170 healthy control subjects. Control subjects were matched by age, race, and time of blood draw.
RESULTS—Resistin levels at baseline were significantly higher in women than in men (P = 0.003) and in case patients than in control subjects for both women (P < 0.001) and men (P = 0.07). After adjustment for matching factors, physical activity, alcohol intake, smoking, and family history of diabetes, the relative risk of type 2 diabetes comparing the highest to the lowest quartile of resistin in women was 2.22 ([95% CI 1.32–3.73]; Ptrend = 0.002). This association was attenuated after further adjustment for BMI (1.51 [0.86–2.65]; Ptrend = 0.20) or C-reactive protein (1.18 [0.68–2.07]; Ptrend = 0.60). A similar but weaker pattern was observed in men.
CONCLUSIONS—Elevated levels of circulating resistin were significantly related to increased risk of type 2 diabetes, which appears to be partially accounted for by adiposity and the inflammatory process.
Footnotes
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Published ahead of print at http://care.diabetesjournals.org on 28 October 2008.
The funding sources had no role in the study conduct and analysis.
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- Accepted October 21, 2008.
- Received September 3, 2008.
- DIABETES CARE
