Impaired Postprandial Metabolism of Apolipoprotein B48–Containing Remnant Particles in Normolipidemic Subjects With Brittle Type 1 Diabetes
- Jenny W. Su, RD1,
- Jennifer E. Lambert2,
- Michael T. Clandinin, PHD2 and
- Spencer D. Proctor, PHD1
- 1Metabolic and Cardiovascular Diseases Laboratory, Alberta Institute for Human Nutrition, University of Alberta, Edmonton, Alberta, Canada
- 2Alberta Institute for Human Nutrition, University of Alberta, Edmonton, Alberta, Canada
- Corresponding author: Spencer D. Proctor, spencer.proctor{at}ualberta.ca
Impaired metabolism of intestinally derived chylomicron remnants has been implicated in the development of atherosclerosis among normolipidemic patients with coronary heart disease (1,2) and, indeed, in other conditions associated with increased vascular disease such as obesity, metabolic syndrome, type 2 diabetes, and familial hypercholesterolemia (3–5). However, the role of these particles in the increased atherosclerotic risk associated with type 1 diabetes is unclear. No studies to date have examined apolipoprotein (apo)B48, a specific marker of chylomicron particle number, in the human type 1 diabetic population.
Nine normolipidemic subjects (five male and four female) with brittle type 1 diabetes and seven healthy normolipidemic …
