Association of Lifestyle Factors With Abdominal Subcutaneous and Visceral Adiposity

The Framingham Heart Study

  1. Esther A. Molenaar, PHD1,
  2. Joseph M. Massaro, PHD2,
  3. Paul F. Jacques, PHD3,
  4. Karla M. Pou, MD4,
  5. R. Curtis Ellison, MD5,
  6. Udo Hoffmann, MD, PHD6,
  7. Karol Pencina2,
  8. Steven D. Shadwick7,
  9. Ramachandran S. Vasan, MD78,
  10. Christopher J. O'Donnell, MD, MPH79 and
  11. Caroline S. Fox, MD, MPH47
  1. 1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Municipal Health Service Utrecht, Utrecht, the Netherlands
  2. 2Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts
  3. 3U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts
  4. 4Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
  5. 5Boston University School of Medicine, Boston, Massachusetts
  6. 6Massachusetts General Hospital Cardiac Magnetic Resonance Positron Emission Tomography Computed Tomography Program, Boston, Massachusetts
  7. 7National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts
  8. 8Department of Cardiology and Preventive Medicine, Boston University School of Medicine, Boston, Massachusetts
  9. 9Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
  1. Corresponding author: Caroline S. Fox, foxca{at}nhlbi.nih.gov

Abstract

OBJECTIVE— The purpose of this study was to assess the relationship between lifestyle factors and abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in a community-based setting.

RESEARCH DESIGN AND METHODS— Cross-sectional associations between lifestyle factors (dietary quality, physical activity, smoking, and alcohol consumption) and SAT and VAT volumes were examined in 2,926 Framingham Heart Study participants (48.6% women, aged 50 ± 10 years).

RESULTS— Diets consistent with the 2005 Dietary Guidelines Adherence Index and greater physical activity were inversely associated with SAT and VAT (P < 0.0001–0.002). In men, former smoking was associated with higher SAT (2,743 ± 56 cm3) compared with current smokers (2,629 ± 88 cm3) or those who never smoked (2,538 ± 44 cm3; P = 0.02). Both former and current smoking was associated with higher VAT (P = 0.03 [women]; P = 0.005 [men]). Women with high amounts of alcohol intake (>7 drinks/week) had lower SAT (2,869 ± 106 cm3) than those who consumed less alcohol (3,184 ± 44 cm3, P = 0.006); significant differences in VAT were not observed (P = 0.18). In men, high amounts of alcohol intake (>14 drinks/week) were associated with higher VAT (2,272 ± 59 cm3) compared with intake of ≤14 drinks/week (2,139 ± 25 cm3, P = 0.04), whereas SAT did not differ (P = 0.91). An increasing number of healthy lifestyle factors were associated with lower SAT and VAT volumes (all P < 0.003).

CONCLUSIONS— Adherence to recommended dietary guidelines and physical activity are associated with lower SAT and VAT volumes. However, both smoking and high alcohol intake are differentially associated with VAT volumes. Further research to uncover the putative mechanisms is warranted.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 15 December 2008.

    Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted December 4, 2008.
    • Received July 25, 2008.
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  1. Diabetes Care vol. 32 no. 3 505-510
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