Renal Function Following Fluorescein Angiography in Diabetic Patients With Chronic Kidney Disease

  1. Yusuke Kameda, MD1,
  2. Tetsuya Babazono, MD, PHD2,
  3. Kensuke Haruyama, MD1,
  4. Yasuhiko Iwamoto, MD, PHD2 and
  5. Shigehiko Kitano, MD, PHD1
  1. 1Department of Ophthalmology, Diabetes Center, Tokyo Women's Medical University School of Medicine, Tokyo, Japan
  2. 2Department of Medicine, Diabetes Center, Tokyo Women's Medical University School of Medicine, Tokyo, Japan
  1. Corresponding author: Tetsuya Babazono, babazono{at}dmc.twmu.ac.jp

Intravenous fluorescein angiography has been widely used in evaluating diabetic retinopathy. Diabetic patients in whom fluorescein angiography is crucial are likely to have chronic kidney disease (CKD) because retinopathy and nephropathy usually progress in parallel. Although numerous reports have been published concerning the development of adverse reactions after fluorescein angiography (1–3), to the best of our knowledge, it has never been debated in the literature whether fluorescein (noniodinated contrast media) induces nephropathy as does iodinated radiocontrast. Therefore, we conducted this hospital-based retrospective cohort study to determine whether fluorescein angiography is associated with deterioration of renal function in diabetic patients with CKD.

Among consecutive diabetic patients undergoing fluorescein angiography to assess retinopathy at the Department of Ophthalmology, …

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