Influence of Adiponectin Gene Polymorphisms on Adiponectin Level and Insulin Resistance Index in Response to Dietary Intervention in Overweight-Obese Patients With Impaired Fasting Glucose or Newly Diagnosed Type 2 Diabetes
- Hye Kyung Chung, RD, PHD1,2,
- Jey Sook Chae, PHD2,3,
- Yae Jung Hyun, PHD2,3,
- Jean Kyung Paik, MS2,4,
- Ji Young Kim, PHD2,3,
- Yangsoo Jang, MD, PHD, FACC3,5,6,
- Hyuck Moon Kwon, MD, PHD7,
- Young Duk Song, MD8,
- Hyun Chul Lee, MD, PHD9 and
- Jong Ho Lee, PHD, RD,2,3,4
- 1Department of Nutrition Services, Youngdong Severance Hospital, Seoul, Korea;
- 2National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea;
- 3Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Korea;
- 4Department of Food and Nutrition, Brain Korea 21 Project, College of Human Ecology, Yonsei University, Seoul, Korea;
- 5Cardiovascular Genome Center, Yonsei University College of Medicine, Seoul, Korea;
- 6Cardiology Division, Cardiovascular Center, Yonsei University College of Medicine, Seoul, Korea;
- 7Department of Cardiology and Cardiovascular Center, Yongdong Severance Hospital, Seoul, Korea;
- 8Department of Endocrinology and Metabolism, National Health Insurance Cooperation Ilsan Hospital, Kyungki Province, Goyang, Korea;
- 9Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- Corresponding author: Jong Ho Lee, jhleeb{at}yonsei.ac.kr.
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H.K.C. and J.S.C. contributed equally to this work.
Abstract
OBJECTIVE The aim of this study was to determine the effect of common adiponectin gene polymorphisms on dietary intervention-mediated changes in adiponectin levels and homeostasis model assessment of insulin resistance (HOMA-IR) indexes.
RESEARCH DESIGN AND METHODS A total of 363 subjects with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes followed a dietary intervention (replacement of cooked refined rice with whole grains and an increase in vegetable intake) and regular walking for 12 weeks without any medication. Adiponectin gene single nucleotide polymorphisms (SNPs) (45, 276, and −11377) were examined in these subjects.
RESULTS After this dietary intervention, fasting glucose levels decreased in all three SNP 45T>G genotype groups. Subjects with the SNP 45TT genotype showed increased adiponectin levels and decreased HOMA-IR indexes. Haplotype analysis revealed that homozygous carriers of the TG haplotype (45TT and 276GG) and heterozygous carriers of the TG haplotype (TG/X) showed a reduction in the HOMA-IR index after adjustment for baseline levels. Significant differences were observed in changes in HOMA-IR indexes and adiponectin concentrations according to the 45-276 TG haplotype in overweight-obese, but not in normal-weight subjects: the greatest decrease in HOMA-IR indexes and the greatest increase in adiponectin levels were shown in overweight-obese subjects with the TG/TG haplotype.
CONCLUSIONS ADIPOQ genetic variants can affect circulating adiponectin levels and insulin resistance indexes in subjects with IFG or newly diagnosed type 2 diabetes in response to dietary intervention.
Footnotes
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- Received November 10, 2008.
- Accepted January 3, 2009.
- © 2009 by the American Diabetes Association.
