Combined Measurement of Fasting Plasma Glucose and A1C Is Effective for the Prediction of Type 2 Diabetes
The Kansai Healthcare Study
- Kyoko Kogawa Sato, MD, PHD1,
- Tomoshige Hayashi, MD, PHD1,
- Nobuko Harita, MD1,
- Takeshi Yoneda, MD1,
- Yoshiko Nakamura, MD, PHD2,
- Ginji Endo, MD, PHD1 and
- Hiroshi Kambe, MD1,2
- 1Department of Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, Japan;
- 2Kansai Health Administration Center, Nippon Telegraph and Telephone West Corporation, Osaka, Japan.
- Corresponding author: Kyoko Kogawa Sato, ksato{at}med.osaka-cu.ac.jp.
Abstract
OBJECTIVE We prospectively assessed whether the combined measurements of fasting plasma glucose (FPG) and A1C were effective for predicting type 2 diabetes.
RESEARCH DESIGN AND METHODS Study participants included 6,736 nondiabetic Japanese men aged 40–55 years. Type 2 diabetes was diagnosed in those who had an FPG ≥126 mg/dl or who were being treated with an oral antidiabetic agent or insulin. The models including FPG, A1C, and both were compared using the area under the receiver operating characteristic (AUROC) curves.
RESULTS During the 4-year follow-up period, we confirmed 659 diabetes cases. In multivariate analysis, both FPG and A1C were independently associated with the risk of type 2 diabetes. The model including both FPG and A1C had a greater AUROC curve than that including FPG alone (0.853 vs. 0.818; P < 0.001) or A1C alone (0.853 vs. 0.771; P < 0.001).
CONCLUSIONS The combined measurement of FPG and A1C was effective for predicting type 2 diabetes.
Footnotes
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received September 4, 2008.
- Accepted January 1, 2009.
- © 2009 by the American Diabetes Association.
