Association Among Sarcoidosis, Type 1 Diabetes, and Charcot Neuro-Osteoarthropathy
- Dario Pitocco, MD1,
- Giuseppe Scavone, MD1,
- Francesco Zaccardi, MD1,
- Giuseppina Gioffrè, MD2,
- Tittania Musella, MD1,
- Francesca Martini, MD1,
- Andrea Manto, MD1,
- Salvatore Caputo, MD1,
- Lorena Mancini, MD2 and
- Giovanni Ghirlanda, MD1
- 1Department of Clinical Pathology, Catholic University School of Medicine, Rome, Italy;
- 2Diabetic Foot Unit, Agostino Gemelli Hospital, Rome, Italy.
- Corresponding author: Dario Pitocco, dario.pitocco{at}rm.unicatt.it.
Sarcoidosis is a multisystemic inflammatory disease. The association between sarcoidosis and type 1 diabetes is rare. We report two cases of sarcoidosis associated with type 1 diabetes complicated by Charcot neuro-osteoarthropathy (CN).
A subject with type 1 diabetes complicated by peripheral and autonomic neuropathy presented cough and cervical lymphadenopathy. The chest computed tomography (CT) scan revealed bilateral hilar lymphadenopathy. A mediastinal lymph node biopsy showed noncaseating giant epithelioid cell granulomas. The immunohistological examination of a follicle showed the prevalence of T-cells. The result of a Mantoux test was negative. Bronchoalveolar lavage was sterile. ACE was absent from bronchoalveolar lavage fluid and increased to 40 UI/l (normal <20 UI/l; colorimetric …
