Prediction of Type 2 Diabetes Using Alternate Anthropometric Measures in a Multi-Ethnic Cohort
The Insulin Resistance Atherosclerosis Study
- Meredith F. MacKay, MSC1,
- Steven M. Haffner, MD2,
- Lynne E. Wagenknecht, DRPH3,
- Ralph B. D'Agostino, Jr., PHD3 and
- Anthony J.G. Hanley, PHD1
- 1Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada;
- 2Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas;
- 3Department of Public Health Sciences, Wake Forest University, Winston Salem, North Carolina.
- Corresponding author: Anthony J.G. Hanley, anthony.hanley{at}utoronto.ca
Abstract
OBJECTIVE To compare different anthropometric measures in terms of their ability to predict type 2 diabetes and to determine whether predictive ability was modified by ethnicity.
RESEARCH DESIGN AND METHODS Anthropometry was measured at baseline for 1,073 non-Hispanic white (nHW), African American (AA), and Hispanic (HA) subjects, of whom 146 developed type 2 diabetes after 5.2 years. Logistic regression models were used with areas under the receiver operator characteristic curve (AROCs) comparing the prediction of models.
RESULTS Waist-to-height ratio (AROC 0.678) was the most predictive measure, followed by BMI (AROC 0.674). Results were similar in nHW and HA subjects, although in AA subjects, central adiposity measures appeared to best predict type 2 diabetes.
CONCLUSIONS Measures of central and overall adiposity predicted type 2 diabetes to a similar degree, except in AA subjects, for whom results suggested that central measures were more predictive.
Footnotes
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received September 12, 2008.
- Accepted January 22, 2009.
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Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
- © 2009 by the American Diabetes Association.
