Cumulative Effect of Oxidative Stress–Related Gene Polymorphisms on Myocardial Infarction in Type 2 Diabetes
- Naoto Katakami, MD, PHD1,
- Ken'ya Sakamoto, MD, PHD1,
- Hideaki Kaneto, MD, PHD1,
- Munehide Matsuhisa, MD, PHD1,
- Keizo Ohno, MD, PHD2,
- Ikki Shimizu, MD, PHD2,3,
- Fukashi Ishibashi, MD, PHD4,
- Takeshi Osonoi, MD, PHD5,
- Atsunori Kashiwagi, MD, PHD6,
- Ryuzo Kawamori, MD, PHD7 and
- Yoshimitsu Yamasaki, MD, PHD1
- 1Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan;
- 2Ehime Prefectural Central Hospital, Matsuyama City, Japan;
- 3Ehime Prefectural Imabari Hospital, Imabari, Japan;
- 4Ishibashi Clinics, Hiroshima, Japan;
- 5Naka Kinen Clinics, Naka City, Japan;
- 6Department of Medicine, Shiga University of Medical Science, Otsu City, Japan;
- 7Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan.
- Corresponding author: Naoto Katakami, katakami{at}medone.med.osaka-u.ac.jp
It is well-known that oxidative stress plays critical roles in the pathogenesis of atherosclerotic diseases. In this study, we examined the association between four common genetic variants related to oxidative stress (glutamate-cysteine ligase modifier subunit (GCLM) C-588T, myeloperoxidase G-463A, human paraoxonase-1 Gln192Arg, and NADPH oxidase p22phox C242T) and the prevalence of myocardial infarction in type 2 diabetic patients.
All type 2 diabetic patients who periodically attended the outpatient diabetes clinics of five participating hospitals were asked to participate in this study. Subjects who were eligible had type 2 diabetes, diagnosed by diabetologists based on World Health Organization criteria, and were aged ≥50 years. A total of 2,561 type 2 diabetic subjects were included: men, 62%; age, mean ± SD 60.9 …
