Acute Effects of Decaffeinated Coffee and the Major Coffee Components Chlorogenic Acid and Trigonelline on Glucose Tolerance

  1. Aimée E. van Dijk, MSC1,
  2. Margreet R. Olthof, PHD1,
  3. Joke C. Meeuse, MSC1,
  4. Elin Seebus, MD2,
  5. Rob J. Heine, MD, PHD2 and
  6. Rob M. van Dam, PHD3,4
  1. 1Department of Health Sciences and the EMGO Institute for Health and Care Research, VU University Amsterdam, the Netherlands;
  2. 2Department of Endocrinology, VU University Medical Center, Amsterdam, the Netherlands;
  3. 3Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts;
  4. 4Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  1. Corresponding author: Margreet R. Olthof, margreet.olthof{at}


OBJECTIVE Coffee consumption has been associated with lower risk of type 2 diabetes. We evaluated the acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance.

RESEARCH DESIGN AND METHODS We conducted a randomized crossover trial of the effects of 12 g decaffeinated coffee, 1 g chlorogenic acid, 500 mg trigonelline, and placebo (1 g mannitol) on glucose and insulin concentrations during a 2-h oral glucose tolerance test (OGTT) in 15 overweight men.

RESULTS Chlorogenic acid and trigonelline ingestion significantly reduced glucose (−0.7 mmol/l, P = 0.007, and −0.5 mmol/l, P = 0.024, respectively) and insulin (−73 pmol/l, P = 0.038, and −117 pmol/l, P = 0.007) concentrations 15 min following an OGTT compared with placebo. None of the treatments affected insulin or glucose area under the curve values during the OGTT compared with placebo.

CONCLUSIONS Chlorogenic acid and trigonelline reduced early glucose and insulin responses during an OGTT.


  • Clinical trial reg. no. NTR1051,

  • The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

    • Received February 9, 2009.
    • Accepted March 12, 2009.
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  1. Diabetes Care vol. 32 no. 6 1023-1025
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