Association of Endogenous Sex Hormones With Diabetes andImpaired Fasting Glucose in Men
Multi-Ethnic Study of Atherosclerosis*
- Laura A. Colangelo, MS1,
- Pamela Ouyang, MD2,
- Kiang Liu, PHD1,
- Peter Kopp, MD3,
- Sherita Hill Golden, MD2,4,
- Adrian S. Dobs, MD, MHS2,
- Moyses Szklo, MD, DRPH4,
- Dhananjay Vaidya, PHD, MPH2,
- Mary Cushman, MD5 and
- Susan M. Gapstur, PHD1
- 1Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois;
- 2Department of Medicine, Johns Hopkins University, Baltimore, Maryland;
- 3Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois;
- 4Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland;
- 5Department of Medicine, University of Vermont, Burlington, Vermont.
- Corresponding author: Laura A. Colangelo, l-colangelo{at}northwestern.edu.
Abstract
OBJECTIVE To assess associations of sex hormones with impaired fasting glucose (IFG) and type 2 diabetes in men.
RESEARCH DESIGN AND METHODS A total of 3,156 African American, Non-Hispanic white, Hispanic, and Chinese-American men aged 45–84 years who participated in the baseline visit of the Multi-Ethnic Study of Atherosclerosis (MESA) were included. Oddsratios and95% CIs for type 2 diabetes and IFG compared with normal fasting glucose for quartiles of hormones were estimated.
RESULTS After adjusting for age, ethnicity, BMI, and waist circumference, IFG and diabetes were associated inversely with total testosterone and sex hormone–binding globulin (SHBG) and positively with estradiol (E2). Dehydroepiandrosterone was positively associated with IFG but not with diabetes. Associations did not differ across ethnic groups.
CONCLUSIONS Regardless of obesity, total testosterone and SHBG were associated inversely and E2 was associated positively with IFG and diabetes in men. Further research is warranted to better understand the underlying biological mechanisms.
Footnotes
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↵*A complete list of the participating Multi-Ethnic Study of Atherosclerosis investigators and institutions can be found at http://www.mesa-nhlbi.org.
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received December 11, 2008.
- Accepted March 5, 2009.
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Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
- © 2009 by the American Diabetes Association.
