Impaired Vascular Reactivity in Healthy First-Degree Relatives of Subjects With Type 2 Diabetes Is Related to Metabolic Factors
- Kelb Bousquet-Santos, PHD1,2,
- Fabricia J. Neves, MSC2,3,
- Eduardo Tibiriçá, MD, PHD4,
- Marcio Nogueira de Souza, DSC5,6 and
- Antonio C.L. Nóbrega, MD, PHD2,3
- 1University of Brasilia, Brasilia, Brazil;
- 2Department of Physiology and Pharmacology and Postgraduate Program in Cardiovascular Sciences, Federal Fluminense University, Niterói, Brazil;
- 3Postgraduate Program in Clinical and Experimental Pathophysiology, Rio de Janeiro State University, Rio de Janeiro, Brazil;
- 4Laboratory of Neuro-Cardiovascular Pharmacology, Oswaldo Cruz Institute, Rio de Janeiro, Brazil;
- 5Department of Biomedical Engineering, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;
- 6Department of Electronics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
- Corresponding author: Antonio C.L. Nóbrega, aclnobrega{at}gmail.com.
Several studies have suggested that vascular changes precede the development of metabolic disorders in first-degree relatives of subjects with type 2 diabetes, indicating that being a first-degree relative of a subject with type 2 diabetes is a risk per se for vascular dysfunction (1–3). However, these studies have failed to control for relevant metabolic and inflammatory variables that are usually altered in first-degree relatives of subjects with type 2 diabetes and are known to impair vascular reactivity (4).
To investigate the hypothesis that vascular reactivity in first-degree relatives of subjects with type 2 diabetes without metabolic disorders is similar to that in a control group without history of type 2 diabetes, 42 first-degree relatives of subjects with type 2 diabetes (79% women; mean ± SD age 33 ± 9 years) and 45 age- and sex-matched control subjects (78% women; age 34 ± 9 years) were recruited. Vascular reactivity was …
