Association Between Circulating Soluble Receptor for Advanced Glycation End Products and Atherosclerosis
Observations from the Dallas Heart Study
- Jason B. Lindsey, MD1,
- James A. de Lemos, MD1,
- Francesco Cipollone, MD2,
- Colby R. Ayers, MS1,
- Anand Rohatgi, MD1,
- David A. Morrow, MD, MPH3,
- Amit Khera, MD, MSC1 and
- Darren K. McGuire, MD, MHSC1
- 1Donald W. Reynolds Cardiovascular Clinical Research Center, the University of Texas Southwestern Medical Center, Dallas, Texas;
- 2Italian Society for the Study of Atherosclerosis-Abruzzo Section, Chieti, Italy;
- 3Brigham and Women's Hospital, Boston, Massachusetts.
- Corresponding author: Darren K. McGuire, darren.mcguire{at}utsouthwestern.edu.
Abstract
OBJECTIVE To determine the association between circulating soluble receptor for advanced glycation end products (sRAGE) and coronary atherosclerosis.
RESEARCH DESIGN AND METHODS Using data from the Dallas Heart Study, a probability-based population sample, the association between plasma levels of sRAGE and coronary artery calcium (CAC) was assessed among 2,571 subjects with complete imaging and sRAGE data.
RESULTS An inverse graded association was observed between sRAGE quartiles and CAC, with CAC prevalence of 28.5% in quartile 1 compared with 15.7% in quartile 4 (P < 0.0001). After multivariable adjustment, the associations between sRAGE levels in the first and second quartiles (versus fourth quartile) and CAC remained statistically significant (adjusted odds ratio 1.71 [95% CI 1.2–2.4] and 1.5 [1.0–2.1], respectively).
CONCLUSIONS sRAGE is a novel biomarker that is inversely associated with coronary atherosclerosis. The role of sRAGE in the pathobiology of atherosclerosis and its potential prognostic and therapeutic implications warrant further investigation.
Footnotes
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received January 12, 2009.
- Accepted April 2, 2009.
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- © 2009 by the American Diabetes Association.
