Automated Ankle-Brachial Pressure Index Measurement by Clinical Staff for Peripheral Arterial Disease Diagnosis in Nondiabetic and Diabetic Patients
- Cécile Clairotte, MD1,
- Sylvie Retout, PHD2,3,4,
- Louis Potier, MD5,
- Ronan Roussel, MD, PHD3,5,6 and
- Brigitte Escoubet, MD, PHD1,3,7
- 1Département de Physiologie-Explorations Fonctionnelles, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Paris, France;
- 2Unité Fonctionnelle de Biostatistiques, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Paris, France;
- 3Université Paris–Diderot, Paris 7, Unité de Formation et de Recherche Médicale, Paris, France;
- 4Institut National de la Santé et de la Recherche Médicale, U738, Paris, France;
- 5Département d'Endocrinologie, Diabétologie et Nutrition, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Paris, France;
- 6Institut National de la Santé et de la Recherche Médicale, U695, Paris, France;
- 7Institut National de la Santé et de la Recherche Médicale, U872, Paris, France.
- Corresponding author: Brigitte Escoubet, brigitte.escoubet{at}inserm.fr.
Abstract
OBJECTIVE Peripheral arterial disease (PAD) is a prognostic marker in cardiovascular disease. The use of Doppler-measured ankle-brachial pressure index (Dop-ABI) for PAD diagnosis is limited because of time, required training, and costs. We assessed automated oscillometric measurement of the ankle-brachial pressure index (Osc-ABI) by nurses and clinical staff.
RESEARCH DESIGN AND METHODS Clinical staff obtained Osc-ABI with an automated oscillometric device in 146 patients (83 with diabetes) at the time of Dop-ABI measurement and ultrasound evaluation.
RESULTS Measurements were obtained in most legs (Dop-ABI 98%; Osc-ABI 95.5%). Dop- and Osc-ABI were significantly related in diabetic and nondiabetic patients with good agreement over a wide range of values. When Dop-ABI ≤0.90 was used as the gold standard for PAD, receiver operating characteristic curve analysis showed that PAD was accurately diagnosed with Osc-ABI in diabetic patients. When ultrasound was used to define PAD, Dop-ABI had better diagnostic performance than Osc-ABI in the whole population and in diabetic patients (P = 0.026). Both methods gave similar results in nondiabetic patients. The cutoff values for the highest sensitivity and specificity for PAD screening were between 1.0 and 1.1. Estimation of cost with the French medical care system fees showed a potential reduction by three of the screening procedures.
CONCLUSIONS PAD screening could be improved by using Osc-ABI measured by clinical staff with the benefit of greater cost-effectiveness but at the risk of lower diagnostic performance in diabetic patients.
Footnotes
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received December 15, 2008.
- Accepted March 21, 2009.
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Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
- © 2009 by the American Diabetes Association.
