Ability of Lipid Accumulation Product to Identify Metabolic Syndrome in Healthy Men From Buenos Aires
- Mariana L. Tellechea, MD1,
- Florencia Aranguren, MD2,
- María T. Martínez-Larrad, PHD3,
- Manuel Serrano-Ríos, MD3,
- Mariano J. Taverna, MD, PHD2,4,5 and
- Gustavo D. Frechtel, MD, PHD1,4
- 1Department of Genetics and Molecular Biology, Laboratory of Molecular Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina;
- 2Division of Diabetology, Hospital “José de San Martín,” University of Buenos Aires, Buenos Aires, Argentina;
- 3Department of Internal Medicine II, Hospital Clínico San Carlos, Madrid, Spain;
- 4Division of Genetics, Hospital “José de San Martín,” University of Buenos Aires, Buenos Aires, Argentina;
- 5Humoral Immunity Institute “Prof. Ricardo A. Margni” (IDEHU), the National Research Council (CONICET) and School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
- Corresponding author: Mariano J. Taverna, taverna1{at}yahoo.fr.
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M.J.T. and G.D.F. contributed equally to this work.
The metabolic syndrome is a constellation of cardiovascular and metabolic risk factors associated with insulin resistance, which predisposes individuals to diabetes, and appears to be a multifactorial risk factor for cardiovascular disease, although its clinical significance remains controversial (1). Since it may become useful to be able to predict who will develop metabolic syndrome, we explored the value of lipid accumulation product (LAP), a novel index of central lipid accumulation, which has been associated with cardiovascular disease (2) and diabetes (3). LAP is based on a combination of waist circumference and triglyceride: [LAP = (WC − 65) × TG for men and (WC − 58) × TG for women] (2), where TG is triglyceride and WC is waist circumference.
We conducted a cross-sectional population-based survey on metabolic syndrome in Argentinian healthy individuals in order to identify single …
