Oral Disposition Index Predicts the Development of Future Diabetes Above and Beyond Fasting and 2-h Glucose Levels
Response to DeFronzo and Abdul-Ghani
- Kristina M. Utzschneider, MD1,2,
- Ronald L. Prigeon, MD3,4,
- Mirjam V. Faulenbach, MD1,2,
- Jenny Tong, MD, MPH1,2,
- Darcy B. Carr, MD, MS5,
- Edward J. Boyko, MD, MPH6,
- Donna L. Leonetti, PHD7,
- Marguerite J. McNeely, MD2,
- Wilfred Y. Fujimoto, MD2 and
- Steven E. Kahn, MB, CHB1,2
- 1Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington;
- 2Department of Medicine, University of Washington, Seattle, Washington;
- 3Geriatric Research Education and Clinical Center, Baltimore Veterans Affairs Medical Center, Baltimore, Maryland;
- 4Division of Gerontology, University of Maryland School of Medicine, Baltimore, Maryland;
- 5Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington;
- 6Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington;
- 7Department of Anthropology, University of Washington, Seattle, Washington.
- Corresponding author: Kristina M. Utzschneider, kutzschn{at}u.washington.edu.
The primary objective of our study was to validate mathematically whether certain measures of insulin sensitivity and insulin release derived from an oral glucose tolerance test (OGTT) are related in a hyperbolic manner and their product thus suitable for use as an estimate of β-cell function (i.e., the oral disposition index). We felt this was an important first step before examining its ability to predict …
