Short Sleep Duration Is Associated With a Blood Pressure Nondipping Pattern in Type 1 Diabetes
The DIAPASOM study
- Anne-Laure Borel, MD1,
- Pierre-Yves Benhamou, MD, PHD1,
- Jean-Philippe Baguet, MD, PHD2,
- Isabelle Debaty, MD1,
- Patrick Levy, MD, PHD3,
- Jean-Louis Pépin, MD, PHD3 and
- Jean-Michel Mallion, MD, PHD4
- 1Endocrinology Department, University Hospital, Pôle Digidune, Joseph Fourier University, Grenoble, France;
- 2Cardiology Department, University Hospital, Bioclinic Radiopharmaceutics Laboratory, INSERM U877, Joseph Fourier University, Grenoble, France;
- 3Rehabilitation and Physiology Department, University Hospital, INSERM ERI 17, Espri EA 3745, Joseph Fourier University, Grenoble, France;
- 4Cardiology Department, University Hospital, Joseph Fourier University, Grenoble, France.
- Corresponding author: Anne-Laure Borel, alborel{at}chu-grenoble.fr.
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J.-L.P. and J.-M.M. contributed equally to this work.
Abstract
OBJECTIVE To assess whether nocturnal blood pressure dipping status in type 1 diabetes is correlated with specific sleep characteristics and differences in nocturnal glycemic profiles.
RESEARCH DESIGN AND METHODS Twenty type 1 diabetic adult patients underwent sleep studies with simultaneous 24-h ambulatory blood pressure monitoring and continuous nocturnal glucose monitoring.
RESULTS Altogether, 55% of patients exhibited blunted blood pressure dipping. They did not differ from the dipper group in age, BMI, or systolic (SBP) and diastolic (DBP) blood pressure. Total sleep period (TSP) was higher in the dipper group (497 ± 30 vs. 407 ± 44 min for dippers and nondippers, respectively, P < 0.001). TSP was correlated with SBP and DBP day-night differences (r = 0.44 and 0.49, respectively). Periods of nocturnal hypoglycemia (i.e., % of TSP with glycemia <70 mg/dl) were longer in the dipper group (8.1 ± 10.7 vs. 0.1 ± 0.4% for dippers and nondippers, respectively, P = 0.02).
CONCLUSIONS Dipping status in type 1 diabetes was associated with longer sleep duration and with hypoglycemia unawareness.
Footnotes
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Clinical trial reg. no. NCT00805974, clinicaltrials.gov.
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received March 4, 2009.
- Accepted June 5, 2009.
- © 2009 by the American Diabetes Association.
