Relationship Between CarotidIntima-Media Thickness and Silent Cerebral Infarction in Japanese Subjects With Type 2 Diabetes
- Kazuhiro Nomura, MD, PHD1,
- Yoshiyuki Hamamoto, MD, PHD2,
- Shiho Takahara, MD2,
- Osamu Kikuchi, MD1,
- Sachiko Honjo, MD1,
- Hiroki Ikeda, MD, PHD1,
- Yoshiharu Wada, MD1,
- Koichro Nabe, MD, PHD1,
- Ryosuke Okumra, MD, PHD3 and
- Hiroyuki Koshiyama, MD, PHD1
- 1Center for Diabetes and Endocrinology, Tazuke Kofukai Medical Research Institute Kitano Hospital, Osaka, Japan;
- 2Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan;
- 3Department of Radiology, Tazuke Kofukai Medical Research Institute Kitano Hospital, Osaka, Japan.
- Corresponding author: Kazuhiro Nomura, nomura-kob{at}umin.ac.jp.
Abstract
OBJECTIVE We examined the relationship between intima-media thickness of common carotid artery (CCA-IMT) and silent cerebral infarction (SCI) with the magnetic resonance imaging (MRI) study in Japanese subjects with type 2 diabetes.
RESEARCH DESIGN AND METHODS The brain MRI study and the carotid ultrasonography were performed in a total of 217 consecutive Japanese subjects with type 2 diabetes. Various risk factors for SCI were examined using multiple logistic analyses.
RESULTS The SCI was found in 60.4% of the diabetic subjects. In the diabetic subjects, age, systolic blood pressure (SBP), pulse wave velocity, and CCA-IMT were significantly higher in the subjects with SCI than in those without it. Multiple logistic analyses indicated that age, SBP, and CCA-IMT were significant and independent risk factors of SCI in the diabetic subjects.
CONCLUSIONS CCA-IMT, but not pulse wave velocity, was independently associated with SCI in Japanese subjects with type 2 diabetes.
Footnotes
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received March 9, 2009.
- Accepted September 10, 2009.
- © 2010 by the American Diabetes Association.
