Adiponectin and Lipoprotein Particle Size
Response to Weiss et al.
- Kokoro Tsuzaki, BSC1,
- Kazuhiko Kotani, MD, PHD1,2,
- Shinji Fujiwara, MD, PHD3 and
- Naoki Sakane, MD, PHD1
- 1Division of Preventive Medicine and Diabetes Education, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;
- 2Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan;
- 3Mima City National Health Insurance Koyadaira Clinic, Tokushima, Japan.
- Corresponding author: Naoki Sakane, .
We read with great interest the recently published study by Weiss et al. (1) on adiponectin and lipoprotein particle size. They indicate that adiponectin is favorably associated with the lipoprotein particle size and subclass distribution independent of adiposity and insulin sensitivity in young adults (1). However, they did not check lifestyle-related factors, such as smoking status, which affect the lipoprotein particle size. Although adiponectin levels are not independently associated with stroke or brain infarction (2), adiponectin levels are associated with an increased risk of initial-onset coronary heart disease in older people (3). Moreover, adiponectin gene single nucleotide …