High Baseline Vitamin C Levels Do Not Prevent a Positive Outcome of a Lifestyle Intervention
Response to Thamer et al.
- 1Department of Medicine, University of Leipzig, Leipzig, Germany;
- 2Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts;
- 3Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany;
- 4German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.
- Corresponding author: Michael Ristow, .
In a recent issue of Diabetes Care, Thamer et al. (1) addressed the question of whether baseline plasma vitamin C levels influence the outcome of a dietary and exercise intervention in 86 individuals at increased risk for developing type 2 diabetes.
Oxidative stress caused by increased formation of reactive oxygen species during physical exercise has previously been proposed to be an important mediator of insulin sensitivity. In a prospective intervention study (2), we have recently shown that regular intake of combined …