High Baseline Vitamin C Levels Do Not Prevent a Positive Outcome of a Lifestyle Intervention

Response to Thamer et al.

  1. Matthias Blüher, MD1,
  2. Michael Stumvoll, MD1,
  3. C. Ronald Kahn, MD, PHD2 and
  4. Michael Ristow, MD3,4
  1. 1Department of Medicine, University of Leipzig, Leipzig, Germany;
  2. 2Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts;
  3. 3Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany;
  4. 4German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.
  1. Corresponding author: Michael Ristow, mristow{at}

In a recent issue of Diabetes Care, Thamer et al. (1) addressed the question of whether baseline plasma vitamin C levels influence the outcome of a dietary and exercise intervention in 86 individuals at increased risk for developing type 2 diabetes.

Oxidative stress caused by increased formation of reactive oxygen species during physical exercise has previously been proposed to be an important mediator of insulin sensitivity. In a prospective intervention study (2), we have recently shown that regular intake of combined …

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