Overall Diet History and Reversibility of the Metabolic Syndrome Over 5 Years
The Whitehall II prospective cohort study
- Tasnime N. Akbaraly, PHD1,2,3,
- Archana Singh-Manoux, PHD1,4,5,
- Adam G. Tabak, MD, PHD1,6,
- Markus Jokela, PHD7,
- Marianna Virtanen, PHD8,
- Jane E. Ferrie, PHD1,
- Michael G. Marmot, PHD1,
- Martin J. Shipley, MSC1 and
- Mika Kivimaki, PHD1,7,8
- 1Department of Epidemiology and Public Health, University College London, London, U.K.;
- 2INSERM U 888, F-34093 Montpellier, France;
- 3University of Montpellier, Montpellier, France;
- 4Centre for Research in Epidemiology and Population Health, INSERM U 1018, Villejuif Cedex, France;
- 5Centre de Gérontologie, Hôpital Ste Périne, Assistance Publique-Hôpitaux de Paris, Paris, France;
- 61st Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary;
- 7Department of Behavioral Sciences, University of Helsinki, Helsinki, Finland;
- 8Finnish Institute of Occupational Health, Helsinki, Finland.
- Corresponding author: Tasnime N. Akbaraly, .
OBJECTIVE We examined the impact of adherence to the Alternative Healthy Eating Index (AHEI), a set of dietary guidelines targeting major chronic diseases, on metabolic syndrome (MetS) reversion in a middle-aged population.
RESEARCH DESIGN AND METHODS Analyses were carried out on the 339 participants (28% women, mean age 56.4 years) from the Whitehall II study with MetS as defined by the National Cholesterol Education Program Adult Treatment Panel III criteria. Reversion was defined as not having MetS after 5 years of follow-up (158 case subjects).
RESULTS After controlling for potential confounders, adherence to AHEI was associated with MetS reversion (odds ratio 1.88 [95% CI 1.04–3.41]), predominantly in participants with central obesity and in those with high triglyceride.
CONCLUSIONS Our findings support the benefit of adherence to AHEI dietary guidelines for individuals with MetS, especially those with central obesity or high triglyceride levels.
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- Received December 1, 2009.
- Accepted July 22, 2010.
- © 2010 by the American Diabetes Association.
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