Utilizing the Second-Meal Effect in Type 2 Diabetes: Practical Use of a Soya-Yogurt Snack
- From the Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, U.K.
- Corresponding author: Roy Taylor, .
M.J.C. and A.J. contributed equally to this study.
OBJECTIVE To evaluate the effect of a prebreakfast high-protein snack upon postbreakfast hyperglycemia.
RESEARCH DESIGN AND METHODS We studied 10 men and women with diet- and/or metformin-controlled type 2 diabetes. Metabolic changes after breakfast were compared between 2 days: breakfast taken only and soya-yogurt snack taken prior to breakfast.
RESULTS There was a significant lower rise in plasma glucose on the snack day. The incremental area under the glucose curve was 450 ± 55 mmol · min/l on the snack day compared with 699 ± 99 mmol · min/l on the control day (P = 0.013). The concentration of plasma free fatty acids immediately before breakfast correlated with the increment in plasma glucose (r = 0.50, P = 0.013).
CONCLUSIONS Consuming a high-protein prebreakfast snack results in almost 40% reduction of postprandial glucose increment. The second-meal effect can be applied simply and practically to improve postbreakfast hyperglycemia in people with type 2 diabetes.
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See accompanying editorial, p. 2709.
- Received March 25, 2010.
- Accepted July 7, 2010.
- © 2010 by the American Diabetes Association.
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