Glycated Albumin and Glycated Hemoglobin Are Influenced Differently by Endogenous Insulin Secretion in Patients With Type 2 Diabetes
- Masafumi Koga, MD, PHD1,
- Jun Murai, MD1,
- Hiroshi Saito, MD, PHD1 and
- Soji Kasayama, MD, PHD2
- 1Department of Internal Medicine, Kinki Central Hospital, Itami, Hyogo, Japan;
- 2Department of Medicine, Nissay Hospital, Osaka, Japan.
- Corresponding author: Masafumi Koga, koga_m{at}kich.itami.hyogo.jp.
Abstract
OBJECTIVE Glycated albumin (GA) relative to A1C is a useful marker of short-term glycemic control. We investigated whether endogenous insulin secretion in type 2 diabetes has different effects on GA and A1C levels.
RESEARCH DESIGN AND METHODS A1C, GA, and GA-to-A1C ratio were compared in 202 type 2 diabetic patients by type of treatment. Effect of β-cell function determined by homeostasis model assessment (HOMA-%β) on GA-to-A1C ratio was examined. In addition, GA-to-A1C ratio was compared between type 2 diabetic patients and 16 patients with type 1 diabetes.
RESULTS In type 2 diabetic patients, GA-to-A1C ratio was significantly higher in those treated with insulin than in those treated with diet or oral hypoglycemic agents. HOMA-%β showed a significant inverse correlation with GA-to-A1C ratio. This ratio was higher in type 1 diabetic patients than in type 2 diabetic patients.
CONCLUSIONS In diabetic patients with decreased insulin secretion, serum GA levels are higher relative to A1C.
Footnotes
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received June 2, 2009.
- Accepted October 14, 2009.
- © 2010 by the American Diabetes Association.
