Labile A1C Is Inversely Correlated With the Hemoglobin Glycation Index in Children With Type 1 Diabetes
- Stuart A. Chalew, MD1,
- Robert J. McCarter, SCD2,
- Jeanine Ory-Ascani, MS3 and
- James M. Hempe, PHD3
- 1Division of Pediatric Endocrinology, Department of Pediatrics, Louisiana State University Health Sciences Center and the Children's Hospital of New Orleans, New Orleans, Louisiana;
- 2Children's National Medical Center, Bioinformatics Unit, Washington, D.C.;
- 3Children's Hospital of New Orleans, Research Institute, New Orleans, Louisiana.
- Corresponding author: Stuart A. Chalew, schale{at}lsuhsc.edu.
Abstract
OBJECTIVE We hypothesized that labile A1C (LA1C) is directly correlated with stable A1C (SA1C) and between-patient differences in SA1C, which are independent of mean blood glucose (MBG).
RESEARCH DESIGN AND METHODS We measured SA1C, LA1C, MBG, and a single clinic capillary glucose (CCG) from 152 pediatric patients with type 1 diabetes. Patients were grouped as high, moderate, or low glycators by hemoglobin glycation index (HGI).
RESULTS LA1C and SA1C were correlated with CCG and MBG. LA1C was not correlated with SA1C (r = 0.06, P = 0.453). LA1C level was significantly associated with glycator group status (P < 0.0019) and CCG (P < 0.0001). Adjusted LA1C levels were highest in the low-HGI patients and lowest in the high-HGI group.
CONCLUSIONS A conventional model of SA1C being directly correlated with LA1C concentration was not confirmed. Between-patient differences in SA1C at the same MBG may be due to complex intracellular factors influencing formation of SA1C from LA1C.
Footnotes
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received December 12, 2008.
- Accepted November 12, 2009.
- © 2010 by the American Diabetes Association.
