Decaffeinated Coffee and Glucose Metabolism in Young Men
- James A. Greenberg, PHD1,
- David R. Owen, PHD2 and
- Allan Geliebter, PHD3
- 1Department of Health and Nutrition Sciences, Brooklyn College of the City, University of New York, New York, New York;
- 2Department of Psychology, Brooklyn College of the City, University of New York, New York, New York;
- 3Department of Psychology, Columbia University and New York Obesity Research Center, St. Luke's Roosevelt Hospital Center, New York, New York.
- Corresponding author: James Greenberg, jamesg{at}brooklyn.cuny.edu.
Abstract
OBJECTIVE The epidemiological association between coffee drinking and decreased risk of type 2 diabetes is strong. However, caffeinated coffee acutely impairs glucose metabolism. We assessed acute effects of decaffeinated coffee on glucose and insulin levels.
RESEARCH DESIGN AND METHODS This was a randomized, cross-over, placebo-controlled trial of the effects of decaffeinated coffee, caffeinated coffee, and caffeine on glucose, insulin, and glucose-dependent insulinotropic polypeptide (GIP) levels during a 2-h oral glucose tolerance test (OGTT) in 11 young men.
RESULTS Within the first hour of the OGTT, glucose and insulin were higher for decaffeinated coffee than for placebo (P < 0.05). During the whole OGTT, decaffeinated coffee yielded higher insulin than placebo and lower glucose and a higher insulin sensitivity index than caffeine. Changes in GIP could not explain any beverage effects on glucose and insulin.
CONCLUSIONS Some types of decaffeinated coffee may acutely impair glucose metabolism but less than caffeine.
Footnotes
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Clinical trial reg. no. NCT00950898, clinicaltrials.gov.
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received August 17, 2009.
- Accepted November 3, 2009.
- © 2010 by the American Diabetes Association.
