Role of Quantitative Bone Scanning in the Assessment of Bone Turnover in Patients With Charcot Foot
- Robert Bem, MD, PHD1,
- Alexandra Jirkovská, MD, PHD1,
- Michal Dubský, MD1,
- Vladimira Fejfarová, MD, PHD1,
- Marie Buncová, MD, PHD2,
- Jelena Skibová, MGR1 and
- Edward B. Jude, MD, FRCP3
- 1Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic;
- 2Department of Nuclear Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic;
- 3Diabetes Centre, Tameside General Hospital, Ashton-Under-Lyne, Lancashire, U.K.
- Corresponding author: Robert Bem, bemrob{at}yahoo.co.uk.
Abstract
OBJECTIVE To assess the new quantitative bone scan parameters as markers of Charcot neuroosteoarthropathy (CNO) activity.
RESEARCH DESIGN AND METHODS Forty-two patients with acute (n = 21) and nonacute (n = 21) CNO underwent quantitative bone scanning. Patients with acute CNO were followed for 3–12 months and bone scans were repeated after treatment. New quantitative parameters were assessed and compared with markers of bone turnover and with skin temperature difference (STD).
RESULTS Significant correlations between quantitative bone scan parameters and bone turnover markers were observed (all P < 0.05). These parameters decreased after treatment of CNO, and its reduction to the baseline value correlated with differences of bone turnover markers and STD (all P < 0.05).
CONCLUSIONS Our study suggests that bone scanning can be used not only for diagnosis of CNO but also for monitoring disease activity by quantitative bone scan parameters.
Footnotes
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received May 26, 2009.
- Accepted November 14, 2009.
- © 2010 by the American Diabetes Association.
