Inflammation Markers and Metabolic Characteristics of Subjects With 1-h Plasma Glucose Levels
- Gianluca Bardini, MD, PHD,
- Ilaria Dicembrini, MD,
- Barbara Cresci, MD and
- Carlo Maria Rotella, MD
- From the Section of Endocrinology, Department of Clinical Pathophysiology, University of Florence, Florence, Italy.
- Corresponding author: Carlo M. Rotella, c.rotella{at}dfc.unifi.it.
Abstract
OBJECTIVE To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes.
RESEARCH DESIGN AND METHODS A cohort of 1,062 subjects was enrolled. After oral glucose load (oral glucose tolerance test), we compared subjects with NGT and pre-diabetes above and below the 1hPG cut point (155 mg/dl). Fibrinogen and leukocytes count (white blood cells [WBCs]) for subclinical inflammation, lipid ratios, insulin sensitivity (Matsuda index) were determined.
RESULTS Patients with NGT and pre-diabetes (1hPG >155 mg/dl) showed a significant increase of inflammatory markers and lipid ratios (for all, P < 0.05). In age-, sex-, and BMI-adjusted analysis, 1hPG was associated with a significantly higher WBC count and fibrinogen (P < 0.05). Patients with elevated 1hPG showed a highly significant lower insulin sensitivity than subjects <1hPG (P < 0.01).
CONCLUSIONS Elevated 1hPG in subjects with NGT and pre-diabetes is associated with subclinical inflammation, high lipid ratios, and insulin resistance. Therefore, 1hPG >155 mg/dl could be considered a new “marker” for cardiovascular risk.
Footnotes
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received July 22, 2009.
- Accepted November 2, 2009.
- © 2010 by the American Diabetes Association.
